To move beyond correlational studies and directly test gene function, we are establishing CRISPR-Cas9-based genetic modification (transfection) of Plasmodium falciparum parasites in the lab. This capability will allow us to knock out, tag or otherwise manipulate candidate genes identified across our research programme- from those implicated in gametocyte sequestration and sex ratio determination to variant antigen expression- and directly test their function in the parasite. As an enabling technology, it underpins several of our ongoing projects rather than sitting within any single one. This work is supported by the Georg Forster Research Fellowship of the Alexander von Humboldt Foundation, in collaboration with Prof. Dr. Friedrich Frischknecht at Heidelberg University Hospital, Germany.