Gametocytes of P. falciparum go through several forms of development in different sites of the human body. The earliest forms of gametocytes develop in tissues of the bone marrow, emerge into circulation when mature and ready to be transmitted to mosquitoes. We have limited understanding how gametocytes arrive in the human bone marrow, which specific parts of the bone marrow tissues they are in, what processes maintains them there, and how they are released back into circulation. In addition, changes in the bone marrow driven by infection-induced inflammation may exert their effects far beyond the acute phase of the malaria infection, such as disrupting immune memory. We are using molecular, immunohistochemical, immunological tools and single cell transcriptomics to perform in-depth investigations in human bone morrow obtained from living and malaria semi-immune individuals. These would allow us to understand the dynamics of gametocyte sequestration in these tissues more fully and comprehensively characterize parasite-induced changes in human bone marrow. We are working in close collaboration with Drs. Joseph Korpisah and Ali Ayamba at UHAS School of Medicine, Dr. William Gyau Dwamena at St Anthony’s Hospital, Dzodze, and Dr. Daniel Yao Dodzie Agbeley at Ho Teaching Hospital, Ho, all in the Volta Region of Ghana. Our international collaborators include Dr. Pietro Alano at ISS, Rome, Italy, Dr. Britta Urban at LSTM, Liverpool, UK and Prof. Oliver Billker, MIMS, Umea, Sweden.